Includes bibliographical references and index.
|Statement||Michael P. Cancro, editor|
|Series||Contemporary immunology, Contemporary immunology|
|LC Classifications||QR185.8.B15 B215 2010|
|The Physical Object|
|Pagination||xiii, 289 p. :|
|Number of Pages||289|
|ISBN 10||1603270124, 1603270132|
|ISBN 10||9781603270120, 9781603270137|
|LC Control Number||2009933798|
BLyS Ligands and Receptors (Contemporary Immunology): Medicine & Health Science Books @ BLyS ligands and receptors. [M P Cancro;] Book: All Authors / Contributors: M P Cancro. Find more information about: Translation of BAFF inhibition from mouse to non-human primate and human.- BLyS/BR3 receptor signaling in the biology and pathophysiology of aggressive B cell lymphomas.- Tipping the scales of survival: The role of BLyS. BlyS ligands and receptors. Ed. by Michael P. Cancro. Humana Press Inc. pages $ Hardcover Contemporary immunology QP The discovery of the family of ligands and receptors, also known as BAFF, transformed the understanding of B-lymphocyte selection, survival, activation, and homeostasis. Discovery of the BLyS (also known as BAFF) family of ligands and receptors has yielded a paradigm shift in our view of B-lymphocyte selection, survival, activation, and homeostasis. Previously, the B-cell antigen receptor (BCR) was viewed as the sole mediator of these parameters, in which BCR signals were not only dominant but were also Brand: Humana Press.
Get this from a library! BLyS ligands and receptors. [M P Cancro;] -- Centers on the BLyS(BAFF) family of ligands and receptors. This book covers basic and translational/clinical aspects of this molecular family's biology. It focuses on the BLyS family's role in the. In the relatively short period since their initial description, 1,2 the B lymphocyte stimulator (BLyS; also termed BAFF) family of ligands and receptors has assumed a prominent position in fundamental B lymphocyte biology, leading to considerable review and commentary. 3,4,5,6,7,8 A growing body of evidence suggests these molecules play essential roles in the selection, Cited by: The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation. Cancro MP(1). Author information: (1)Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA , USA. [email protected] by: B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene. BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived TNF-like molecule (CD antigen; cluster of differentiation ).Aliases: TNFSF13B, BAFF, BLYS, CD, .
Cell-surface receptors are membrane-anchored proteins that bind to ligands on the outside surface of the cell. In this type of signaling, the ligand does not need to cross the plasma membrane. So, many different kinds of molecules (including large, hydrophilic or "water-loving" ones) may act as ligands. A typical cell-surface receptor has three. Abstract. The TNF family ligands BAFF/BLyS and APRIL play important roles in the homeostasis and function of B cells. BAFF binds to the receptors BAFF-R/BR3, BCMA, and TACI, whereas APRIL interacts with BCMA, TACI, and sulfated side chains of by: 1. BLyS Ligands and Receptors (Contemporary Immunology) by BLyS Ligands and $ Ligands Receptors and BLyS (Contemporary by Immunology) Immunology) by Ligands (Contemporary Receptors BLyS and. Description. Further, BLyS and APRIL influence the various B cell pools differently, based in part on disparate expression of the three receptors within each subset. The ligands, BLyS and APRIL, share 50% homology at the protein level and exhibit several other by: